Hypoxia in microscopic tumors
نویسندگان
چکیده
منابع مشابه
Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy.
Tumor hypoxia is commonly observed in primary solid malignancies but the hypoxic status of subclinical micrometastatic disease is largely unknown. The distribution of hypoxia in microscopic tumors was studied in animal models of disseminated peritoneal disease and intradermal (i.d.) growing tumors. Tumors derived from human colorectal adenocarcinoma cell lines HT29 and HCT-8 ranged in size from...
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We breathe air that is 21% oxygen, but some of our tissues get by on 7%, and many tumor cells on 1% or less. Tumors cope with very low oxygen concentration , or hypoxia, in several ways. The best-studied mechanism is activation of a transcription factor, hypoxia-inducible factor 1 (HIF-1), which has emerged as a promising target for cancer therapy. The fi rst clinical trials of HIF inhibitors a...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2008
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.02.037